question:You are an AI assistant. Provide a detailed answer so user don’t need to search outside to understand the answer. Given the question: Information: - An epitope, also known as antigenic determinant, is the part of an antigen that is recognized by the immune system, specifically by antibodies, B cells, or T cells. For example, the epitope is the specific piece of the antigen to which an antibody binds. The part of an antibody that binds to the epitope is called a paratope. Although epitopes are usually non-self proteins, sequences derived from the host that can be recognized (as in the case of autoimmune diseases) are also epitopes. - A phosphoprotein is a protein that is posttranslationally modified by the attachment of either a single phosphate group, or a complex molecule such as 5'-phospho-DNA, through a phosphate group. The target amino acid is usually serine, threonine, or tyrosine residues (mostly in eukaryotes), or aspartic acid or histidine residues (mostly in prokaryotes). - In immunology, an antigen is a molecule capable of inducing an immune response on the part of the host organism, though sometimes antigens can be part of the host itself. In other words, an antigen is any substance that causes an immune system to produce antibodies against it. Each antibody is specifically produced by the immune system to match an antigen after cells in the immune system come into contact with it; this allows a precise identification of the antigen and the initiation of a tailored response. The antibody is said to "match" the antigen in the sense that it can bind to it thanks to adaptations performed to a region of the antibody; because of this, many different antibodies can be produced, with specificity to bind many different antigens while sharing the same basic structure. In most cases, an antibody can only bind one specific antigen; in some instances, however, antibodies may bind more than one antigen. - Leukemia, also spelled leukaemia, is a group of cancers that usually begin in the bone marrow and result in high numbers of abnormal white blood cells. These white blood cells are not fully developed and are called "blasts" or "leukemia cells". Symptoms may include bleeding and bruising problems, feeling tired, fever, and an increased risk of infections. These symptoms occur due to a lack of normal blood cells. Diagnosis is typically made by blood tests or bone marrow biopsy. The exact cause of leukemia is unknown. Different kinds of leukemia are believed to have different causes. Both inherited and environmental (non-inherited) factors are believed to be involved. Risk factors include smoking, ionizing radiation, some chemicals (such as benzene), prior chemotherapy, and Down syndrome. People with a family history of leukemia are also at higher risk. There are four main types of leukemia acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), chronic lymphocytic leukemia (CLL) and chronic myeloid leukemia (CML) as well as a number of less common types. Leukemias and lymphomas both belong to a broader group of tumors that affect the blood, bone marrow, and lymphoid system, known as tumors of the hematopoietic and lymphoid tissues. Treatment may involve some combination of chemotherapy, radiation therapy, targeted therapy, and bone marrow transplant, in addition to supportive care and palliative care as needed. Certain types of leukemia may be managed with watchful waiting. The success of treatment depends on the type of leukemia and the age of the person. Outcomes have improved in the developed world. The average five-year survival rate is 57% in the United States. In children under 15, the five-year survival rate is greater than 60 to 85%, depending on the type of leukemia. In children with acute leukemia who are cancer-free after five years, the cancer is unlikely to return. In 2012, leukemia developed in 352,000 people globally and caused 265,000 deaths. It is the most common type of cancer in... - Benzene is an important organic chemical compound with the chemical formula CH. The benzene molecule is composed of 6 carbon atoms joined in a ring with 1 hydrogen atom attached to each. Because it contains only carbon and hydrogen atoms, benzene is classed as a hydrocarbon. - B-lymphocyte antigen CD20 or CD20 is an activated-glycosylated phosphoprotein expressed on the surface of all B-cells beginning at the pro-B phase (CD45R+, CD117+) and progressively increasing in concentration until maturity. - Polyclonal antibodies (pAbs) are antibodies that are secreted by different B cell lineages within the body (whereas monoclonal antibodies come from a single cell lineage). They are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope. - Plasma cells, also called plasma B cells, plasmocytes, plasmacytes, or effector B cells, are white blood cells that secrete large volumes of antibodies. They are transported by the blood plasma and the lymphatic system. Plasma cells originate in the bone marrow; B cells differentiate into plasma cells that produce antibody molecules closely modeled after the receptors of the precursor B cell. Once released into the blood and lymph, these antibody molecules bind to the target antigen (foreign substance) and initiate its neutralization or destruction. - Rituximab ( trade names Rituxan , MabThera and Zytux ) is a chimeric monoclonal antibody against the protein CD20 , which is primarily found on the surface of immune system B cells . Rituximab destroys B cells and is therefore used to treat diseases which are characterized by excessive numbers of B cells , overactive B cells , or dysfunctional B cells . This includes many lymphomas , leukemias , transplant rejection , and autoimmune disorders . It is on the World Health Organization 's List of Essential Medicines , the most important medications needed in a basic health system . It has a wholesale price of between 159.00 and 2,480.00 USD per vial as of 2014 . - Monoclonal antibodies (mAb or moAb) are antibodies that are made by identical immune cells that are all clones of a unique parent cell. Monoclonal antibodies can have monovalent affinity, in that they bind to the same epitope (the part of an antigen that is recognized by the antibody). In contrast, polyclonal antibodies bind to multiple epitopes and are usually made by several different plasma cell (antibody secreting immune cell) lineages. Bispecific monoclonal antibodies can also be engineered, by increasing the therapeutic targets of one single monoclonal antibody to two epitopes. - Mast/stem cell growth factor receptor (SCFR), also known as proto-oncogene c-Kit or tyrosine-protein kinase Kit or CD117, is a receptor tyrosine kinase protein that in humans is encoded by the KIT gene. Multiple transcript variants encoding different isoforms have been found for this gene. KIT was first described by the German biochemist Axel Ullrich in 1987 as the cellular homolog of the feline sarcoma viral oncogene v-kit. Given the information above, choose from the list below the object entity that exhibits the relation 'has part' with the subject 'rituximab'. Choices: - a - affinity - b - blood - carbon - dna - mast - one - part - plasma - stem - system - t - v The answer is:

question:You are an AI assistant. You will be given a task. You must generate a detailed and long answer. Please answer the following question: Write a multi-choice question for the following article: Article: Sometimes you need to make phone calls to get a job. Calling is the first step where you can show your ability to an employer. Here are some tried and true tips: Get the person responsible You need to talk directly to the person who would supervise you. In a small business, you might ask to speak to the "person in charge". In a larger one, you would ask for the name of the person in charge of the particular department you're interested in. Get the name of the person If you don't have the name of the person you need to speak to, ask for it. Usually, you will be given the supervisor's name and your call will be transferred to him or her. Get past the receptionist In some cases, receptionists and secretaries will try to screen out your call. If they find out that you're looking for a job, they may transfer you to the Personnel Department or ask you to send an application or resume. Here are some ways to keep from getting screened out: * Call back Call back a day later and say you are getting ready to send some correspondence to the person who manages such and such. You want to use the correct name and title and request that they give you this information. And this approach usually gets you what you need. Say "thank you" and call back in a day or so. Then ask for the supervisor or manager by name. * Call when the secretary is out You are likely to get right through if you call when the receptionist is out to lunch. Other good times are just before and after normal work hours. Less experienced staff members are likely to answer the phone and put you right through. Ask three times for an interview Sometimes, the supervisor you contact just simply rejects you. Then, you can try asking three times for an interview! Although this approach does not always work, asking the third time works more often than most people would believe. Arrange a time If the person agrees to an interview, arrange a specific date and time. Answer:

question:You are an AI assistant that follows instruction extremely well. Help as much as you can. Answer the following question: Pick one category for the following text. The options are - company, educational institution, artist, athlete, office holder, mean of transportation, building, natural place, village, animal, plant, album, film or written work. Hadena silenides - Hadena silenides is a species of moth of the Noctuidae family. It is found in Portugal Spain from Mauretania to Egypt Israel Lebanon Syria Jordan the Arabian Peninsula Iraq and Iran.Adults are on wing from January to April in one generation in Israel. Answer:

question:You are an AI assistant. User will you give you a task. Your goal is to complete the task as faithfully as you can. While performing the task think step-by-step and justify your steps. On a stress! not looking forward to today at all!! Select your answer from the options. What is the sentiment of this tweet? Available options: i. negative. ii. positive....I think the answer is